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Posts Tagged ‘leptin resistance’

always hungry leptin resistance

You would think people who are overweight or obese would never feel hungry—after all, they have all that extra fat to burn. But in a cruel twist of metabolic trickery, carrying excess fat can actually make you hungrier thanks to a phenomenon called leptin resistance.

What is leptin?

Leptin is a “satiety” hormone secreted by fat cells that tells the brain when you have had enough to eat. Eating causes the secretion of leptin, which signals that the stomach is full and it’s time to stop eating. Between meals or during long periods without food, leptin levels drop, triggering hunger and motivating you to eat and replenish the body’s energy stores.

Leptin resistance causes you to always feel hungry

Because fat cells secrete leptin, overweight and obese people should never feel hungry. Unfortunately, the reverse happens. Excess fat secretes too much leptin, bombarding leptin receptors on cells. Eventually these cells become overwhelmed and shut down their leptin receptors to protect themselves. This is called leptin resistance—leptin can no longer get into the cells to deliver their message that the stomach is full and it’s time to stop eating.

Hence the leptin-resistant person always feels hungry and is prone to overeat, even if she or he is carrying plenty of fat. In addition to causing chronic hunger, leptin resistance doubly vexes the overweight person by promoting fat storage and making it tough to lose weight.

Leptin serves other roles beyond hunger and satiety. It is also important for fertility, libido, and puberty. Leptin resistance could explain why obese girls are 80 percent more likely to start puberty earlier than girls of normal weight.

High triglycerides block leptin

High triglycerides have been shown to block leptin. Diets high in alcohol, sugars and carbohydrate-rich foods, such as breads, pasta, rice, and potatoes, raise triglycerides considerably. High triglycerides have been shown to block the ability of leptin to pass into the brain to tell it you’re full.

Diet can reverse leptin resistance and chronic hunger

The key to unwinding leptin resistance is to adopt a diet that will restore leptin sensitivity. The eating habits that typically lead to being overweight or obese—overeating and eating too many sweets and starchy foods, processed foods, and foods fried in industrialized fats—also lead to leptin resistance, high triglycerides, and hence the feeling of always being hungry.

To restore leptin sensitivity, diminish chronic hunger, and release excess fat, consider the following leptin facts and begin making the changes you need to your own diet and lifestyle.

  • Regular exercise, particularly strength training and interval training, lowers leptin.
  • Sugar, corn syrup, and high fructose corn syrup found in sweets and sodas make the brain resistant to leptin. Sweets also raise triglycerides so leptin can’t reach the brain.
  • Healthy fats activate leptin’s satiety switch. Eat coconut oil, butter, ghee, olive oil, avocado, salmon, etc. as part of a lower-carb diet.
  • Omega-3 fatty acids regulate leptin sensitivity. Ask your practitioner whether a fish or krill oil supplement may help you.
  • Overeating causes leptin resistance. Ditch the sodas, sweets, processed foods, and high-carbohydrate foods, which trigger cravings in many people. Healthy fats and sufficient protein curb cravings. Consider hypnotherapy, acupuncture, or other tools to address an eating disorder that may cause you to overeat.

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Question

I learned I have intolerances and allergies to certain foods, and that I need to avoid those foods if I want to lose weight. Isn’t it just a matter of eating fewer calories?

Answer

Some people find they can’t lose weight through calorie restriction alone. When that happens several issues need to be investigated. One of the most important is food intolerances. Eating foods to which you are allergic or intolerant will prevent weight loss.

Food intolerances cause inflammation

Food intolerances and allergies create inflammation, and inflammation prevents weight loss. Every time you eat gluten, dairy, eggs, soy, corn, or some other food that may be a problem for you, you create inflammation in your body.

Leaky gut is a primary culprit

For many people today, a variety of foods trigger inflammation. This is due largely to intestinal permeability, or “leaky gut,” which allows undigested food particles to slip into the bloodstream through damaged and inflamed intestinal walls. Leaky gut is very common today due to poor diets, excessive sweets, chronic stress, and other maladies of modern life. Gluten intolerance and celiac disease are also common and cause leaky gut.

As these food particles circulate throughout the body the immune system responds by attacking and destroying them for removal, just as it would respond to a viral or bacterial infection. Unfortunately, if the food is eaten regularly, this keeps the immune system constantly at work, hence creating chronic inflammation. Symptoms can be obvious in the way of joint pain, skin issues, abdominal pain, or even brain fog, memory loss, or moodiness. Sometimes the inflammation is not obvious, yet a person finds she or he can’t lose weight.

Inflammation halts weight loss

Studies show the immune compounds that cause inflammation also make insulin receptors less sensitive, creating insulin resistance. As a result glucose can’t get into cells and blood sugar becomes too high. The body lowers blood sugar by converting it to fat for storage. Insulin resistance also hinders fat burning.

Inflammation also has been shown to cause leptin resistance, which stimulates hunger and promotes fat storage. Furthermore, excess body fat secretes immune messenger cells that trigger inflammation, promoting a vicious cycle that prevents weight loss.

Although moderating caloric intake and exercising are recommended for weight loss, effective and lasting weight loss depends in part on tackling chronic inflammation and food sensitivities.

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